Sep 22, 2020

Infants Born to Women With SARS-CoV-2 Show Few Adverse Outcomes

Infants born to women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) showed few adverse outcomes, according to a study published in Clinical Infectious Diseases.

Among 263 initial infants enrolled in the Pregnancy Coronavirus Outcomes Registry (PRIORITY), adverse outcomes, including preterm birth, neonatal intensive care unit (NICU) admission, and respiratory disease did not differ between infants born to mothers who tested positive for SARS-CoV-2 and those born to mothers who tested negative.

Among infants born to mothers who tested positive for SARS-CoV-2, the estimated incidence of a positive infant SARS-CoV-2 test was low at 1.1% (0.1%, 4.0%), and infants had minimal symptoms.

“The babies are doing well, and that’s wonderful,” said Valerie J. Flaherman, MD, University of California San Francisco, San Francisco, California. “When coronavirus disease 2019 [COVID-19] first hit, there were so many strange and unfortunate issues tied to it, but there was almost no information on how COVID-19 impacts pregnant women and their newborns. We didn’t know what to expect for the babies, so this is good news.”

PRIORITY began in March 2020, shortly after the pandemic began to peak in the United States. The project was designed for pregnant women with suspected or confirmed COVID-19, with the goal of better understanding how pregnant and postpartum women and their infants are affected by the virus.

The new paper reports on live births among 179 mothers with a positive test for SARS-CoV-2 and 84 mothers who had a negative test. The births occurred at more than 100 US hospitals. The average age of the mothers was 31 years. Among women testing positive, 146 (81%) were symptomatic; among those testing negative, 53 (63%) were symptomatic.

Of the 263 infants in total, 44 were admitted to the NICU, but no pneumonia or lower respiratory tract infections were reported during the study. Among the 56 infants assessed for upper respiratory infection, it was reported in 2 infants with COVID-positive mothers, and in 1 with a COVID-negative mother.

“Overall, the initial findings regarding infant health are reassuring, but it’s important to note that the majority of these births were from third trimester infections,” said senior author Stephanie L. Gaw, MD, University of California San Francisco. “The outcomes from our complete cohort will give the full picture of risks throughout pregnancy.”

Two infants born to mothers who tested positive in the third trimester were reported to have birth defects, each with multiple congenital anomalies reported. One infant had cardiac, vertebral, renal, and pulmonary anomalies, while the other had facial, genital, renal, brain, and cardiac anomalies. One mother who tested negative reported an infant with gastrointestinal, renal, and cardiac anomalies.

Reference: https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciaa1411/33770645/ciaa1411.pdf

SOURCE: University of California San Francisco

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